The effects of nonoxynol- 9 on sperm

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Comparison of the action of nonoxynol-9 and chlorhexidine on sperm. The effect on sperm motility of nonoxynol-9 chlorhexidine diacetate was compared in semen and cervical mucus. The effects of nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective transmembrane migration ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50 (ec 50) were 0. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50 (ec50) were 0. Original research article complementary effects of propranolol and nonoxynol-9 upon human sperm motility elsevier david r. John aitken the inhibitory effects of nonoxynol-9, dl- and d-propranolol upon human sperm motility were determined in vitro. All spermicidal agents contain a surfactant, usually nonoxynol-9 (n-9), that immobilizes or kills sperm on contact they also provide a mechanical barrier. Spermicides used alone are 75 to 85 effective in preventing pregnancy, but may be used with another barrier method, such as condoms or diaphragms. The results also demonstrated that gramicidin-d and edta had no significant effect on the sperm acrosome that is, the majority of sperm remained acrosome-intact similar to fresh, untreated sperm. Nonoxynol-9, however, appeared to completely disrupt the acrosome, as demonstrated by the majority of sperm being acrosome-reacted (ritc). Products containing nonoxynol-9 have been used as spermicidal contraceptives for many years, but limited data have been published describing the long-term effects of nonoxynol-9 use on the vaginal microbial ecosystem. This longitudinal study was conducted to examine the effects of nonoxynol-9 on the vaginal ecology. Sperm maturation may be impaired by alpha-chlorohydrin, antiandrogens, or sulphasalazine, and sperm motility in the female genital tract can be inhibited by vaginal spermicides such as nonoxynol-9 and by propranolol. As a spermicide, it attacks the acrosomal membranes of the sperm, causing the sperm to be immobilized. Nonoxynol-9 is the active ingredient in most spermicidal creams, jellies, foams, gel, film, and suppositories. Objective nonoxynol-9 (n-9) is a nonionic surfactant used as the active ingredient in the majority of commercially available spermicides.

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